This is the online documentation of NONMEM.

• User Guide provides NLME fundamentals, model building, and examples,
• Reference Manual provides details on control records, options, keywords, and API.
• Cookbook provides modeling techniques and How-To's.

This document is largely derived from existing NONMEM Guides and aims to be mostly comprehensive; where additional detail is required, it explicitly refers back to the guides, particularly

Guide V: Introductory Guide;

Guide VI: PREDPP Guide;

Guide VIII: Help Guide;

Introduction to NONMEM 7.

All examples mentioned as "example/example-name" can be found in the example directory.

See development notes here. You may also submit NONMEM-related issues here.

Copyright by the Regents of the University of California 1994, 2009.

Copyright by ICON plc 2011, 2012, 2013,2015,2017,2020,2024.

All rights reserved.

The NONMEM name and logo are registered trademarks of the Regents of the University of California.