Reference manual

This is the online Reference Manual for NONMEM. It contains details of control records and their options, syntax of abbreviated code, data labels, and outputs. For advanced users it also provides instructions for customization, and details of NONMEM's API. This manual is part of NONMEM documentation that is largely derived from existing NONMEM Guides (particularly Guide V, Guide VI, Guide VIII, and INTRODUCTION to NONMEM 7) and aims to be mostly comprehensive; where additional detail is required, it explicitly refers back to the guides.

The other components of NONMEM documentation are NONMEM User Guide and NONMEM Cookbook.

Copyright and trademark

The NONMEM name and logo are registered trademarks of the Regents of the University of California.

Notations

In this document we use the following notations to describe functions, arguments, and options.

Any or all arguments in [ ] are optional, e.g. [foo bar], and equivalently [foo] [bar], means foo and bar are both optional.
Options delimited by | cannot be used together, e.g. option=a|b means one must choose to specify option=a or option=b.
... indicates reaptable arguments, e.g. filename ... means one can supply multiple files, and [label|value]... means label1 value2 value3 label4 is allowed.
A keyword with "(NONMEM version)" appended indicates the record/option as introduced in that version. For example "$DEFAULT (NM74)" means the record was introduced in NONMEM v7.4.
Starting in v7.2 NONMEM is no longer case-sensitive to reserved keywords, reserved variables, or user-defined variables.