• NLUSER=100 Maximum number of logical I/O units user may use.
• LTH=100 MAX. NO. OF THETA'S. Dynamically sized, or set by user via $SIZES record
• LVR=30 MAX. NO. OF ETA'S + EPS'S. Dynamically sized, or set by user via $SIZES record
• LVR2=20 MAX. NO. OF ETA'S PERMITTED WHEN LAPLACIAN METHOD IS USED. Value may be over-ridden by user via $SIZES record Value may be over- ridden by user via $SIZES record
• NO=250 MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD
• MMX=10 MAX NO. OF MIXTURE SUBPOPULATIONS. Dynamically sized, or set by user via $SIZES record
• LNP4=4000 SIZE OF COMMON NMPRD4. Value may be over-ridden by user via $SIZES record
• LSUPP=4050 MAX. NO. OF POINTS OF SUPPORT WITH NONPARAMETRIC ESTIMATE. Value may be over-ridden by user via $SIZES record
• LIM7=2 SIZE OF BUFFER 7. DO NOT GO LOWER THAN 2. Value may be over- ridden by user via $SIZES record
• LWS3=9000 SIZE OF WORKING SPACE 3 AT LEAST AS LARGE AS: NS*NOETAS**2, WHERE NS IS THE NO. OF DIRECTIONS USED WITH THE STIELTJES METHOD, AND NOETAS IS THE NUMBER OF ETA'S. Value may be over-ridden by user via $SIZES record
• MAXIDS=10000 MAX. NO. OF INDIVIDUALS IN DATA SET. Dynamically sized, or set by user via $SIZES record
• LIM1=10000 SIZE OF BUFFER 1. Value may be over-ridden by user via $SIZES record
• LIM2=100000 SIZE OF BUFFER 2. Value may be over-ridden by user via $SIZES record
• LIM3=10000 SIZE OF BUFFER 3. DO NOT GO LOWER THAN 2. Value may be over-rid- den by user via $SIZES record
• LIM4=1000 SIZE OF BUFFER 4: LIM4=NUMBER OF SUBJECTS. Value may be over- ridden by user via $SIZES record
• LIM5=200 SIZE OF BUFFER 5. Value may be over-ridden by user via $SIZES record
• LIM6=400 SIZE OF BUFFER 6. Value may be over-ridden by user via $SIZES record
• LIM8=200 SIZE OF BUFFER 8. Value may be over-ridden by user via $SIZES record
• LIM10=100000 SIZE OF BUFFER 10. Value may be over-ridden by user via $SIZES record
• LIM11=25 SIZE OF BUFFER 11. Value may be over-ridden by user via $SIZES record
• LIM13=1000 SIZE OF BUFFER 13: LIM13=NUMBER OF SUBJECTS. Value may be over- ridden by user via $SIZES record
• LIM15=1000 SIZE OF BUFFER 15: LIM15=NUMBER OF SUBJECTS. Value may be over- ridden by user via $SIZES record
• LIM16=400 SIZE OF BUFFER 16. Value may be over-ridden by user via $SIZES record
• LSTEXT=70000 AT LEAST (MAXOMEG*(MAXOMEG+1)/2+MAXPHETA+5)*NUMTEXT. LSTEXT is maximun number of characters to a single line of the raw output file specified by $EST FILE=. where NUMTEXT is number of charac- ters needed to represent a number and its delimiter. For exam- ple, FORMAT=,1PE12.5 takes up NUMTEXT=13 characters.
• LSFORM=2048 LSFORM is the character length of FORMAT TFORMATL,RFORMATL, per- taining to the full length of LFORMAT, RFORMAT for the $TABLE record.
• MAXRECID=200 Maximum number of records in any individual record. For use by PREDPP. Value may be over-ridden by user via $SIZES record
• PC=30 MAX. NO. OF COMPARTMENTS MAXIMUM IS 99. Value may be over-ridden by user via $SIZES record
• PCT=30 MAX. NO. OF MODEL EVENT TIMES. Value may be over-ridden by user via $SIZES record
• MAXNRDS=PC MAXNRDS: MAX. NO. OF DELAY COMPARTMENTS FOR ADVAN16, ADVAN17, and ADVAN18. YOU MAY WANT TO MAKE IT LOWER THAN PC AND SAVE MEMORY Value may be over-ridden by user via $SIZES record
• PAST_SIZE=4000 RESOLUTION (NUMBER OF DETAILED POINTS) FOR DELAY COMPARTMENTS STORAGE FOR ADVAN16 AND ADVAN17. Value may be over-ridden by user via $SIZES record
• PCT_BIG=10000 MAX. NO. OF MODEL EVENT TIMES THAT NMTRAN CAN PROCESS.^M ! PG: SIZE OF GG; MAX. NO. OF BASIC+ADDITIONAL PK PARAMS.^M ! (MAX- IMUM IS PCT+99)^M
• PIR=700 SIZE OF COMPACT DA/DP/DT ARRAYS. Value may be over-ridden by user via $SIZES record
• PD=50 CHANGED TO INCREASE DATA ITEMS PER DATA RECORD FROM 20 TO 50 IT IS ALSO SIZE OF VDATREC DATA ARRAY. THIS IS DONE TO SEPARATE VDA- TREC AND VRESWRES VARIABLES/ Dynamically sized, or set by user via $SIZES record.
• MAXIC=90 MAXIC: MAXIMUM NUMBER OF ACTIVE INFUSIONS FOR PREDPP. Value may be over-ridden by user via $SIZES record
• PDT=500 MAXIMUM NUMBER OF TABLE ITEMS/PRED-DEFINED ITEMS. Value may be over-ridden by user via $SIZES record
• PAL=50 NO. OF ADDITIONAL AND LAGGED DOSES. Value may be over-ridden by user via $SIZES record
• MAXFCN=1000000 MAX. NO. OF CALLS IN GENERAL NON-LINEAR MODELS IMAX IN MODULE PRCOM_INT OVERRIDES. Value may be over-ridden by user via $SIZES record
• STIELTJ_SIZE=101 The next four are for internal use, pertaining to various addi- tional weighted residual diagnostics
• MAXXNAME=40
• MAXVRESWRES=39
• MAXVRESN=9
• MXNAME=40
• DIMTMP=500 RELATED TO THE NUMBER OF USER-DEFINED VARIABLES. Value may be over-ridden by user via $SIZES record
• DIMCNS=500 RELATED TO THE TOTAL NUMBER OF CONSTANTS. Value may be over-rid- den by user via $SIZES record
• DIMNEW=1000 RELATED TO THE TOTAL NUMBER OF INTERMEDIATE VARIABLES. Value may be over-ridden by user via $SIZES record
• DIMQ=99999 ARRAY SIZE FOR LOGICAL CONDITIONS
• FL=49 LOGICAL UNIT NUMBER FOR FLIB
• DIMVRB=1000 MAX. NO. OF LINES OF VERBATIM CODE
• PL=10 MAXIMUM DEPTH OF NESTED IF STATEMENTS
• NFUNCX=100 MAXIMUM NUMBER OF USER FUNCTIONS.
• NVECX=100 MAXIMUM NUMBER OF USER VECTORS.
• MAXOTHER=1000 Maximum number of filenames listed on $SUBROUTINE OTHER=filename
• SD=30 LENGTH OF DATA LABEL
• FSD=67000 LENGTH OF CONTROL STREAM FILE STRING (ALSO, MULTIPLE LINES CON- CATENATED WITH & MAY NOT EXCEED FSD)
• FSD1=67001 LENGTH OF CONTROL STREAM FILE STRING
• SCO=30 STRING LENGTH OF NUMBER IN $THETA, $OMEGA, $SGIGMA RECORDS.
• SDF=24 LENGTH OF DATA ITEM
• NFSIZES=50 NUMBER OF ITEMS LISTED IN FSIZES FILE
• NPRSIZES=14 NUMBER OF PREDPP ITEMS IN PRSIZES.F90
• CONSTANTS FOR Monte Carlo, EM methods
• MAX_EXTRA=20 Numer of $EST statements allowed per problem
• NPOPMIXMAX=10 Now dynamically sized to MAXIMUM NUMBER OF SUB-POPULATIONS FOR MIXTURE MODELS MMX. Or, set by user via $SIZES record
• MAXOMEG=70 Now dynamically sizes to LVR, OR MAXIMUM OMEGA DIMENSION ETAS. Or, set by user via $SIZES record (but should be left alone)
• MAXPTHETA=90 Now dynamically sized to LTH, MAXIMUM NUMBER OF THETA, PLUS LOWER TRIANGLE OF SIGMA. THUS, IF NUMBER OF THETAS IS N, AND DIMENSION OF SIGMAS IS M, THEN NEED MAXPTHETA=N + M*(M+1)/2. OR, may be set by user via $SIZES record (but should be left alone).
• MAXITER=210 Maximum number of previous iterations to incorporate into Monte Carlo convergence tests Effective CITER is <=MAXITER
• ISAMPLEMAX=10 FOR SAEM METHOD, EFFECTIVE ISAMPLE<=ISAMPLEMAX
• MAXSIDS=100 MAXIMUM NUMER OF SUPER ID ITEMS IN DATA SET
• MAXSIDL=0 MAXIMUM LEVEL OF SUPER IDS. MAXSIDL=0 MEANS NO SUPER IDS. Default 0, until $LEVEL is used, in which case it will be dynami- cally sized.
• MAXFTEXT=100 Maximum of PRDERR message lines
• PNM_MAXNODES=100 MAXIMUM NUMBER OF PARALLELIZATION NODES
• PNM_BUFFER_SIZE=100000 INTERNAL BUFFER SIZE, FOR EFFICIENT PACKAGING AND SENDING BETWEEN PROCESSES

More information including descriptions of the buffers may be found in the INTRODUCTION TO NONMEM 7.

There is only one version of SIZES (i.e., there is no longer a SIZES_reg or SIZES_big).

Many NONMEM and NM-TRAN arrays are allocated dynamically at run time.

NM-TRAN creates a subroutine FSIZESR for NONMEM. FSIZESR contains values for some parameters (e.g., LVR) that are exactly what is needed for the current problem, and contains 0's for parameters that NM-TRAN cannot assess. Default values for parameters that are 0 in FSIZESR are obtained by NONMEM from the file SIZES.f90.

Note that file FSIZES is a convenient reference for users but not used by NONMEM. SUBROUTINE FSIZESR in FSUBS is what is actually used during the NONMEM run.

NM-TRAN creates a file PRSIZES.f90 for PREDPP. PREDPP arrays are allocated statically but may be re-compiled at run time using parameters defined in prsizes.f90. Some constants in prsizes are assessed for the current problem; others are copied from default values in SIZES.f90.

(See Guide VI, Chapter VII.A.)

The user may override many of the parameter values in FSIZES and prsizes with the $SIZES record. Any value specified by $SIZES will override both the default in SIZES.f90 and the value that NM-TRAN would have specified.

(See $sizes)

As of NONMEM 7.3, NMTRAN determines the maximum number of observation records (MDV=0) that occur in any subject, among all data files used in the entire control stream file. If this value is greater than the NO value listed in SIZES.f90, it will set NO to this larger size. Thus, users no longer have to be conscientious of sizing the NO parameter. However, there is no guarantee that NMTRAN will correctly assess NO for the entire scope of the control stream file for all types of problems. Should this occur, NONMEM may issue an error, and the user will need to set the NO value with a $SIZES record.

Constants that may be changed with $SIZES record:

LTH LVR LVR2 LPAR MMX MAXIDS NO PD MAXOMEG MAXPTHETA

Consants that are also in prsizes:

PC PCT PIR PD PAL MAXFCN

REFERENCES: Guide III, section V.3.0 REFERENCES: Guide Introduction_7