This is the online user’s guide for NONMEM. It provides fundamentals of nonlinear mixed-effects model, basic model building using NONMEM, and NONMEM example models for population PK analysis. This guide is part of NONMEM documentation that is largely derived from existing NONMEM Guides (particularly Guide V, Guide VI, Guide VIII, and INTRODUCTION to NONMEM 7) and aims to be mostly comprehensive; where additional detail is required, it explicitly refers back to the guides.

The other components of NONMEM documentation are NONMEM Reference Manual and NONMEM Cookbook.

We recommend working through this guide, and refer to the NONMEM Reference Manual when necessary to clarify programming issues.